Background: Acne vulgaris is a multifactorial dermatological disorder affecting pilosebaceous units, with increasing demand for natural therapeutic alternatives due to antibiotic resistance concerns and adverse effects of conventional treatments.

Objective: To formulate and evaluate topical cream preparations containing Azadirachta indica extract for antiacne application, optimizing pharmaceutical parameters for stability, safety, and potential therapeutic efficacy.

Methods: Seven cream formulations (F1-F7) were developed using varying concentrations of neem extract (3-7 mL), beeswax (4-12 g), liquid paraffin, borax, methyl paraben, and lecithin following standard emulsification techniques. Pre-formulation studies included comprehensive extract characterization through organoleptic evaluation and solubility analysis. Formulations were systematically evaluated for physical characteristics, washability, irritability potential, phase separation, homogeneity, and greasiness using established pharmaceutical testing protocols.

Results: Neem extract demonstrated characteristic dark green/brown coloration, strong pungent odor, extremely bitter taste, and preferential oil solubility. Solubility studies revealed free solubility in methanol, solubility in ethanol, high solubility in acetone, and practical insolubility in aqueous systems. Among seven formulations tested, F3 achieved optimal pharmaceutical properties with smooth texture, absence of irritancy, phase separation stability, positive homogeneity, and non-greasy characteristics, scoring 5/5 in comparative evaluation. F4 and F5 demonstrated acceptable properties with scores of 4/5 each.

Conclusion: Azadirachta indica extract can be successfully incorporated into stable cream formulations with favorable pharmaceutical characteristics. Formulation F3 exhibited superior properties suitable for topical antiacne application, warranting further antimicrobial efficacy studies and clinical evaluation.

Keywords: Azadirachta Indica, Neem Extract, Antiacne Cream, Topical Formulation, Pharmaceutical Evaluation, Natural Products.