Diabetes mellitus, a chronic metabolic disorder, has emerged as a global health burden, prompting a surge in research on plant-based therapeutics. Schleichera oleosa (Lour.) Oken, a traditionally valued medicinal plant, has gained attention for its potential antidiabetic properties attributed to its rich phytochemical composition. This review aims to comprehensively evaluate the antidiabetic activity of Schleichera oleosa by examining its phytochemical constituents, underlying mechanisms of action, and findings from both in vitro and in vivo studies. An extensive literature search was performed using databases such as PubMed, Google Scholar, ScienceDirect, and Google. Studies indicate that Schleichera oleosa contains bioactive compounds such as flavonoids, tannins, triterpenoids, and phenolics, particularly quercetin, which contributes to its hypoglycemic effect. The plant exhibits antidiabetic activity via mechanisms such as inhibition of α-amylase and α-glucosidase, antioxidant defense enhancement, and pancreatic β-cell protection. Both in vitro and in vivo models have shown promising results in blood glucose regulation and oxidative stress reduction. Schleichera oleosa holds significant promise as a natural antidiabetic agent. Further clinical investigations and standardization of its bioactive compounds are warranted to validate its therapeutic potential and facilitate its integration into evidence-based herbal medicine.

Keywords: Diabetes Mellitus, Schleichera Oleosa, Quercetin, Oxidative Stress, Antidiabetic Agent