Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder characterized by metabolic disturbances and chronic inflammation. Fenugreek (*Trigonella foenum-graecum*) is known for its medicinal properties and has been investigated for its anti-inflammatory effects. This study evaluates the in vitro anti-inflammatory potential of fenugreek seed extract using protein denaturation assays, membrane stabilization assays, and Erythrocyte Sedimentation Rate (ESR) tests. Celecoxib was used as a standard drug for comparison. The results indicated that fenugreek extract exhibited significant anti inflammatory activity comparable to celecoxib. This suggests its potential role as a natural therapeutic agent for inflammation associated with PCOS. Further studies are required to confirm its efficacy through in vivo and clinical trials.