Fat accumulations in liver cells cause (NAFLD), a disorder linked to oxidative stress, metabolic syndrome, and obesity. It was examine if Ficus Bengalensis aqueous prop-roots extract (APREFB) protected rats from (HFHF) fatty liver disease. Five sets of thirty male rats were used: Group-1: control group with control diet), Group-2: HFHF group as a positive control (rats fed a HFHF diet) for 20 weeks, Group-3: HFHF+APREFB (250 mg/kg) group, Group-4: HFHF+ APREFB (500 mg/kg) group, and Group-5: HFHF+ OrlistaI120 mg/kg) group. To examine fasting blood glucose levels and pertinent metabolic markers, blood samples were drawn at various intervals. Giving tissue enzymes, hyperglycemia profile, oxidative stress indicators in liver tissue, and histological analysis were used to assess the course of NAFLD. Our f indings demonstrated that 16 weeks of HFHF treatment resulted in hyperglycemia, hyperlipidemia, and an increase in liver enzymes. In addition, the HFHF GSH levels and higher hepatic MDA to the control group.

A histological analysis confirmed the findings, revealing pathological alterations in the HFHF group. However, when APREFB was taken orally, all of these alterations were better in comparison to HFHF+ OrlistaI120 mg/kg and positive control groups. The liver index, blood glucose level, and weight increase all significantly decreased (P < 0.05) as a result of APREFB. When compared to the group fed an HFHF diet alone, APREFB at all experimental doses significantly reduced the levels of triacylglycerol, cholesterol, low-density lipoprotein, and malondialdehyde in plasma and significantly raised the level of cholesterol (P < 0.05).

This study demonstrated that APREFB reduced the oxidant impact, hyperglycemia, and dyslipidemia linked to a high-fat, high-fructose diet. At last, we are able to Our results imply that APREFB ingestion might have protective effects against the advancement of NALFD. Further research on APREFB’s prophylactic potential in humans is necessary since it should be viewed as an alternative natural prophylactic medication against this disease.

Keywords: Aqueous Prop-roots Extract of Ficus Bengalensis (APREFB), High fat–high Fructose (HFHF), Prophylactic Medication.