Breast self-examination is a common screening method which is done by the individuals by themselves as an effort to detect the presence of breast cancer in its earliest stages by physically examining both the breasts for the possibility of any lump, distortions, or swelling etc. Materials and Methods: The quotative research approach was used in this study. The present study was to evaluate the effectiveness of Structured Teaching Programme on knowledge score regarding Breast Self-Examination among student Nurses. Purposive sampling technique was used to select the sample, the sample size was 52.Results: The f inding of the study revealed that a majority (42.3%) of the student nurses were between 21-23 years of age, followed by 36.5% in the 24-26 years range, with 21.2% falling between 18-20 years. Notably, no students were aged 26 years or above. In terms of family structure, 63.5% of students belonged to nuclear families, 28.8% to joint families, and 7.7% to extended families. Conclusion: the findings of the study concluded that there was a significant improvement in students’ knowledge regarding BSE, with the pre test knowledge score averaging 62.10 and the post-test score rising to 77.50. These findings indicate a substantial increase in knowledge of Breast Self-Examination following Structured Teaching Programme.