The likelihood of extended hospitalisation, increased healthcare expenses, and patient suffering resulting from post-orthopaedic surgical site infections (SSIs) means that the postoperative burden is still somewhat heavy. These diseases also provide a great difficulty for orthopaedic surgeons. Along with higher rates of morbidity and death, post-orthopaedic SSIs have been linked to increased sensitivity to negative health consequences. SAP, or systemic antibiotic prophylactic therapy, lowers the SSI risk. Different characteristics of closed fractures, open fractures, arthroplasty, and percutaneous fixation affect the data and antimicrobial treatment. Implementing SAP requires careful balancing of good antibiotic stewardship practices with reducing the occurrence of SSIs. This approach essentially stops antibiotic resistance from developing as well as the frequency of unpleasant effects. The aim of this study was to investigate the present body of knowledge on the use of surgical antibiotic prophylaxis in orthopaedic surgery and investigate the possible effects connected with the improper dosage of antibiotics.