Marigold (Tagetes species) has been used for centuries in traditional medicine and more recently in modern therapeutic applications. This review comprehensively examines the therapeutic benefits and processing methods of various Tagetes species. It explores the phytochemical composition of marigolds, focusing on key bioactive compounds such as lutein, zeaxanthin, and essential oils. The review discusses the antioxidant, anti-inflammatory, antimicrobial, and wound-healing properties of marigold extracts, supported by in vitro and in vivo studies. Potential applications in ophthalmology, dermatology, and cancer prevention are also covered. Various processing techniques, including advanced extraction methods, are evaluated for their efficiency in isolating bioactive compounds. Additionally, the safety and toxicity profiles of marigold preparations are addressed, along with their potential interactions with conventional medications. The review examines current market trends and future prospects for marigoldbased products in the pharmaceutical and nutraceutical industries. This comprehensive review aims to provide researchers, healthcare professionals, and industry stakeholders with a thorough understanding of the therapeutic potential and processing considerations of Tagetes species, highlighting areas for future research and development.