The Adivasi, often referred to as Indigenous people or original inhabitants, constitute approximately 17 million prospective tribes in India. The term “designated Tribe” holds a legal designation. According to the 2011 census, the number of planned tribes in India is 104,281,034, which equals 8.6% of India’s total population. This paper aims to examine the health profile of Tribals in 3 ITDA spots of Kurnool District, Andhra Pradesh. Objectives: The main aim of the study was to assess the health profile and shed light on the top 10 diseases prevalent in the 3 selected ITDA spots of Kurnool district, as well as to promote the Unani system through mobile medical camps under the Tribal Sub Plan (TSP). Additionally, it aims to analyse the health profile and determinants of tribes in the study area. Methodology: This study focuses on the health profile of the 3 ITDA spots based on OPD data, including the distribution of patients by sex and age groups, and identifying the top 10 common diseases in these areas. Results: A total of 2583 individuals attended the OPD of the 3 ITDA spots in the year 2022-2023. Among them, the top 10 diseases were identified, and their distribution by sex and age group was analysed. Conclusion: The present study revealed that most of the tribals in the study area suffered from Sual o surfa (Cough), Sardi wa Zukam (Common cold & coryza), and Humma (Fever), which are common in the 3 ITDA spots, followed by Warm I Halaq (Pharyngitis), Suda (Headache), and Polyarthritis.