To attain the necessary concentration of medication in the systemic circulation for the predicted pharmacological response, solubility the phenomenon of solute dissolving in solvent to produce a homogeneous system is a crucial characteristic to consider. The primary challenge in developing formulations for both novel chemical entities and generics is their low water solubility. Formulation scientists face a significant obstacle in solubility. The Classification of Biopharmaceutics states that APIs from Classes II and IV have reduced bioavailability, dissolution, and solubility. The article covers a range of technologies that can be used to make drugs that aren't very water-soluble more soluble. These include crystal engineering, pharmaceutical salts, drug nanocrystals, solid dispersion methods, polymeric micelle preparation, cosolvents, micelles, microemulsions, and emulsion formation. Physical and chemical drug modifications, crystal engineering, salt formation, solid dispersion, surfactant use, micronization, solid dispersions, nano sizing, cyclodextrin complexation, and other advanced methodologies are primarily described in this review. Other methods also contribute to improving solubility and bioavailability. It was an effort to talk about different complexation methods and to quickly point out their possible uses, as well as their technical and economic limits.