Biologically active natural pharmaceutical excipients and their substructures have long been valuable in drug development and formulation strategies. The article explores biologically active gums, resins and mucilage used as pharmaceutical excipients and their applications in phytopharmaceuticals drug development. Being natural products with therapeutic activities, these compounds present a broad scope in their refinement and applications in today’s pharmaceuticals. The article casts light on pharmaco-therapeutically active excipients that give an insight into medications today and their practical implementation in pharmacotherapy.