2-deoxy-D-glucose (2-DG) is a glucose moiety having 2 hydroxyl group replaced by hydrogen that can inhibit increased glycolytic flux &some other metabolic process of viral replication. The treatment of viral infection is very challenging due to intricate structure & metabolism of viruses. The 2-deoxy-D-glucose (2- DG) in SARS-COV-2 infection induces glycolysis, impairs mitochondrial function damages infected cells. Keys Words: 2-deoxy-D-glucose, SARS-COV-2, Covid-19, virus literature.