Background: Pancreatic pseudocyst is a common complication of acute and chronic pancreatitis and continues to present diagnostic and therapeutic challenges. Management ranges from conservative treatment to minimally invasive and surgical interventions depending on cyst characteristics and complications.

Objective: To evaluate the clinical profile of patients with pancreatic pseudocyst and assess treatment modalities with respect to outcomes, complications, and recurrence.

Methods: This hospital-based prospective observational study was conducted in the Department of General Surgery, Assam Medical College and Hospital, Dibrugarh. A total of 62 patients diagnosed with pancreatic pseudocyst were included. Clinical evaluation, laboratory investigations, ultrasonography, and contrast-enhanced computed tomography were performed. Patients were managed conservatively, by percutaneous drainage, or surgically based on clinical presentation and cyst characteristics. Outcomes were assessed in terms of resolution, complications, recurrence, and mortality.

Results: Most patients were males (83.9%), predominantly in the 41–50 years age group. Alcohol-related pancreatitis was the leading etiological factor (61.3%). Most pseudocysts were single (71.0%), located in the lesser sac (45.2%), and measured 6–10 cm (48.4%). Surgical management was the most common treatment modality (51.6%), with cystogastrostomy being the most frequently performed procedure. Complete resolution was achieved in 77.4% of patients. Recurrence occurred in 12.9%, mainly in conservatively or percutaneously managed cases. Infection was the most common complication, while mortality was low (1.6%).

Conclusion: Pancreatic pseudocyst predominantly affects middle-aged males and is commonly associated with alcohol related pancreatitis. Surgical management, especially internal drainage, provides favorable long-term outcomes with low recurrence in symptomatic and complicated cases.

KEYWORDS: Pancreatic Pseudocyst, Pancreatitis, Surgical Management, Cystogastrostomy, Outcomes, Complications.