ROLE OF BIOMARKERS IN THE DIAGNOSIS, MANAGEMENT IN GASTROINTESTINAL DISORDERS AND GI CANCERS

Author: Rajan Mishra, Dr. Sahil Gupta, Dr. Kulbhushan Haldeniya, Dr. Akhilesh Patel, Dr. Ashutosh Upadhya, Dr. Ravindra Pal Singh

Abstract:
Background: Assessment of gastrointestinal (GI) biomarkers involved in diagnosis of GI diseases and cancers is difficult. Measurement of biomarkers is a valuable tool for the assessment of inflammatory bowel diseases and malignancies. Objectives: To review the role of various biomarkers in diagnosis of GI disease. Methods: The primary studies have been screened from different databases , PMC , NLM , Scopus , Google scholar etc. all the information have been reviewed and considered after consulting with medical subject headings. Result: Many research efforts in the GI field have been placed on finding non-invasive and reliable biomarkers of GI disease that can be easily tested in body fluids without impacting the quality of life of patients. Unfortunately, the ideal biomarker is yet to be discovered and recent studies have investigated the possibility to increase the accuracy of such measurements by combining different markers. Conclusions: we provide an update about the current knowledge on GI biomarkers, focusing on disease diagnosis, correlation with endoscopic findings, and prediction of relapse. We also summarize composite scores of clinical and laboratory markers that have been recently proposed in various scenarios of GI diseases.